Sports-related Concussions

Development of an ultrasensitive saliva test for diagnosing sports-related concussions (SRCs)

This project addresses a prominent public health concern: contact sports players currently lack an objective clinical method to diagnose and monitor recovery from concussions. This project utilizes an ultra- sensitive detection platform (single molecule array technology; Simoa) to develop a salivary biomarker panel that quantifies sports-related concussion (SRC) biomarkers in noninvasively collected saliva, which can be used to objectively diagnose SRCs and to determine when return to participation (RTP) is safe and appropriate. The salivary biomarker profile will be evaluated via statistical analysis in regard to whether the panel can provide reliable benchmarks regarding concussion severity and objective parameters to inform decision-making regarding RTP.